Bio-Identical Hormone Replacement Therapy

Bio-Identical Hormone replacement therapy:  Bio-Identical hormone therapy is just that hormones that are “identical” in molecular structure to your own hormones. As we age, we notice sometimes subtle other times dramatic changes in sleep, concentration, body weight, and mood.  These symptoms are often due to hormone depletions. As a whole body, stress, diet. Lifestyle, gut, can cause hormones to fluctuate dramatically. Wendy Finkelstein PA-C takes these factors into consideration when balancing hormones and utilizes specialized test from state of the art laboratories that include not just blood but urine to evaluate markers of poor hormonal detoxification and genetics that play a very important role.

 

Almost everyone over the age of 40 (and in many cases over 30) begins to experience hormone imbalance. Over your lifetime, you are exposed to environmental and dietary toxins, which contribute to the natural decline of hormones as you age. Though there are many forms of hormone imbalance, menopause is among the most common in women. Menopause is the time in a woman’s life when ovarian production of estrogen, progesterone and testosterone begin to decline. Although menopause is medically defined as the time during which a woman ceases to menstruate for at least 12 months, the onset can occur up to 10 years before that, in a stage referred to as perimenopause.

Women can suffer from symptoms of hormonal imbalance at any point in the life cycle, as hormonal changes can be affected by several factors, including stress, diet, pregnancy, childbirth, perimenopause, and menopause. This is why most practitioner recommend that women have their hormone levels checked by age 30 to establish a baseline.

Men: Symptoms of Declining Testosterone

  • Loss of energy

  • Loss of muscle mass or decreased results with workouts

    • Increase in body fat and/or breast tissue

    • Loss of libido

    • Loss of morning erection

    • Depression

 

Proven Benefits of Bioidentical Hormone Replacement Therapy

  • Reduction in symptoms brought on by menopause and andropause

  • Better sleep

  • Facilitated weight loss

  • Increased lean muscle mass/decreased body fat

  • Increased skin elasticity/fewer wrinkles

  • Decreased anxiety and depression

  • Improved memory and mental faculty

  • Higher energy level with greater stamina

  • Increased bone density

Women: Symptoms of Hormone Imbalance

  • Irritability, mood swings and depression

  • Loss of libido

  • Low energy levels

  • PMS, headaches and foggy thinking

  • Trouble sleeping

  • Weight gain or unstable blood sugar

  • Vaginal dryness and/or pain with intercourse

  • Urinary incontinence

  • Hot flashes and night sweats

Men & Hormone Therapy

For men, most complaints stem from a gradual decline in testosterone. Symptoms of hormonal decline in men can manifest in many ways, from emotional, psychological, and behavioral changes to loss of energy, decreased stamina and sexual dysfunction. Although a decline in hormone levels will occur with age in virtually all men, there is no way to predict who will experience andropause symptoms of sufficient severity to seek medical help. This is why it is critically to know that low testosterone levels can severely impact a man’s quality of life and may expose him to more significant health problems like heart disease, osteoporosis and stroke.

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Mindset / Life Coaching

Wendy, along with her team of psychosynthesis life coaches, recognizes and supports the necessary shifts that are essential for optimal healing to take place. 

Wendy strongly believes that he best opportunities  to heal occur when the physical body is in service to the soul, also known as Nephesh. These two components must be synthesized in order for the body to be awakened to a new frequency.

​Connect with Wendy by scheduling an appointment through the calendar.

For a free 30 minute consultation click here:

 

Metabolic Performance Panel and Micronutrient Testing

Wouldn’t it be great to know which vitamins you may be missing? Which nutrients you could easily incorporate into your diet? Which supplements you can add to your daily routine? Most of us think we know what a healthy diet looks like, but we also hear conflicting information all around us. eat for your blood-type, eat smaller meals more often, eat all your meals in an 8 hour period, low calorie, low fat, low carb, high fat, high protein, take probiotics, take prebiotics, take this supplement, take

this vitamin drink this shake.

 

Link to Urinary metabolomic testing from Physicians Lab offers the most accurate results for biomarkers in the body. Physicians Lab’s method of collecting is simple and fast. The testing is easy to complete, requiring only a few drops of a first morning void urine sample. Physicians Lab has developed a novel LCMS/ MS assay to quantify 50 curated biomarkers in human urine. The results provide detailed information on how the body is metabolically balanced and are driven by algorithms to determine outcome-based recommendations which are supported by peer reviewed clinical literature and population wide association studies. The report is an on-demand analysis of phenotypical information to be used independently or compliment nutrigenomic testing. Providing personalized nutrition for individuals allows for an optimal diet, improved metabolic performance and disease prevention.

The Metabolic Performance Profile creates a personalized approach to optimal health through examining certain biomarkers of genetics, diet, lifestyle, environment, metabolism and detoxification to make assessments in the following areas:

  • Cellular Energy Production

  • B-Vitamin and Methylation

  • Inflammation and Oxidative Stress

  • Muscle Assessment

  • Gut Assessment

  • Essential and Non-Essential Amino Acids

At end of every section button/link to schedule or say “Test your Metabolic Performance” with link to schedule

 
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Genetic Testing

More than 75% of all patients have significant genetic weaknesses (SNPs) in the most important nutritional metabolism pathways.Millions of patients expend their valuable income on nutritional supplements without knowledge or scientific proof of nutritional need or benefit. Without genetic validation of enzyme function, many supplements are not effectively delivered at the cellular level, therefore, the patient can be wasting time and money with nutritional ingredients that have little to no benefit. Just because a patient has a (+ / +) or even a (+ / -), does not mean they have or will have a disease. It just means they have a predisposition to a condition, if exposed to the right environment, it may ignite that gene expression. A Genomic SNP is like a crack in the foundation of a bridge. …What if we could reinforce the cracks and were able to guide patients on how to do so? Having knowledge of where the cracks are in our foundation, would tell us where not to put the most stress.

Immune response, inflammation, methylation, energy production, hormonal health, GI health and detoxification continue to emerge as the cornerstones of health and wellness. These cornerstones are all founded in how patients express their genes (epigenetics) and metabolize products (metabolomics). Along the pathway of gene expression and metabolism, there are places where the road is rocky. By identifying genetic predispositions as bumps in the road and making recommendations on how to modify both epigenetic expression and metabolism, practitioners have a road map to avoid the rocky roads and keep each patient on smooth pavement. Through a series of specialized genetic single nucleotide polymorphisms (SNPs) analyses, Physicians Lab can make supplementation and lifestyle recommendations for each patient’s specific genetic makeup and then track epigenetic progress through monitoring the affected metabolic pathways of each genetic predisposition in either Hormone or Metabolic Performance Profiles. With Nutrigenomic testing, practitioners can identify common SNPs and use that information to either change the expression of those genes or support the pathways below the altered genes by introducing missing cofactors and nutrients.

 

Peptide Therapy

CJC/Ipamorelin

As we age our release of growth hormone decreases leading to almost every aspect of aging. The history of unsafe prescribing of growth hormone itself in the fitness industry led to this incredible safe and effective peptide. CJC Ipamorelin amplifies the releasee of your own naturally produced growth hormone from the pituitary and prolongs it leading to benefits such as:

  • Improved bone density and muscle mass

  • Weight loss

  • Improved memory and cognition

  • Libido

  • Immune system

  • Repair and recovery

  • Improved skin elasticity and reduction in wrinkles

 

Tesamorelin 

 

Wendy calls this peptide the  Rolls Royce of secratogogues. While it does an amazing job of slimming the waist line, Tesamorelin  a growth hormone releasing hormone analog also has benefits including positive nootropic (brain) effects as well as  reducing triglycerides. Tesamorelin has subsequently been shown to decrease carotid intima media thickness (cIMT), Visceral adipose tissue (VAT), and C-reactive protein (CRP) in a recent study. It has not been shown to significantly affect other pituitary hormones and their respective mechanisms in the body. Additionally, it has been shown to improve cognitive function for healthy older adults and also for people with mild cognitive impairment who are at an increased risk of progressing to Alzheimer’s disease

BPC 157 

BPC 157 aka body protection compound (BPC) was discovered in and isolated from human gastric juice.  It has been demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments. In addition, BPC 157 seems to protect organs and to prevent ulcers of the stomach. BPC-157 acts systemically in the digestive tract to combat leaky gut, IBS, gastro-intestinal cramps, and Crohn’s disease. This peptide is also shown to decrease pain in damaged areas. Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood ‑ow to damaged tissues.

 

GHKcu  “Copper Peptide”

This is one of Wendy’s new favorite skin care items. This peptide used as a cream 3-4 nights a week signals the stem cells in our skin to produce more collagen. Copper peptides are small, naturally occurring protein fragments that have high affinity for copper ions, which are critical to normal body function. GHK-Cu has a variety of roles in the human body including, but not limited to, promoting activation of wound healing, attracting immune cells, anti-oxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth. i There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. First, it seems to act as a potent protector of tissue and anti-inflammatory agent that controls the oxidative damage that occurs post-tissue injury. Further, it then plays a big role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age. Thus, there is an increase in inflammation, cancerous activity, and tissue destruction.

 

Semax

Semax is a peptide best known for its nootropic, neuroprotective, and neurogenic/neurorestorative propertiesIn the U.S. and around the world, Semax is the basis for a number of drugs that are used in clinical practice for the treatment of CNS diseases (ischemic brain stroke, dys-circulatory encephalopathy, optic nerve atrophy, etc.) and to enhance adaptability under extreme conditions in healthy persons.

 

POTENTIAL BENEFITS

Some of the benefits of Semax may include:

  • Increased attention and short-term memory

  • Improved Non-proliferative Diabetic Neuropathy

  • Can help during recovery from Stroke/Hypoxia

  • Improved Glaucoma Optic Neuropathy

  • May act as an Analgesic (pain reliever) by inhibiting Enkephalin breakdown

  • Can be helpful in the treatment of ADHD

  • Nootropic (cognitive-enhancing) effects

  • Neuroprotection: may help protect the brain from various types of stress and damage

HOW DOES SEMAX WORK?

Semax increases brain-derived neurotrophic factor (BDNF) levels. BDNF is among the most active neurotrophins, which are chemicals that help to stimulate and control neurogenesis, the birth of new neurons in the brain. 

BDNF has been shown to play a role in neuroplasticity, which allows nerve cells in the brain to compensate for injury and adapt to new situations or changes in the environment. Basically, BDNF helps to support the survival of existing neurons and encourages the growth, regeneration, and creation of new neurons and synapses. 

Semax also helps reduce the breakdown of enkephalins. Enkephalins are mainly involved in decreasing pain, reducing inflammation, preventing cancer cell growth, and increasing immune cell activity. They also play a role in memory, learning, emotional behavior, and pain. Balanced enkephalins levels are needed to maintain normal brain function. These early findings have led some researchers to suggest that Semax may have some potential as a pain reliever, although much more research would be needed to confirm these preliminary cell-based findings.

Based on what Semax can do for brain function and health, its capabilities as a treatment option are continually being developed.

 

STUDY EXAMPLES

In one clinical trial, 100 patients recovering from an ischemic stroke added Semax to their conventional recovery therapy. It was reported to accelerate the restoration of damaged brain functions — especially movement-related symptoms. In another trial of almost 200 people with reduced brain blood flow (“cerebrovascular insufficiency”), it was reported that Semax reduced overall brain damage and could potentially reduce the risk of additional future strokes. Semax was generally well-tolerated and caused relatively few side-effects.

Other studies focused on optic nerve disease reported that patients using Semax, when combined with other anti-inflammatory treatments, may have helped reduce the progression and severity of optic nerve disease.

 

ADMINISTRATION

Semax is a prescription from a compounding pharmacy. It comes in the form of a nasal spray which is administered daily. It is most often combined with another peptide called Selank for additive effects.

RESEARCH

Gavrilova SA1, Golubeva AV, Lipina TV, Fominykh ES, Shornikova MV, Postnikov AB, Andrejeva LA, Chentsov IuS, Koshelev VB. Protective effect of peptide semax (ACTH(4-7)Pro-Gly-Pro) on the rat heart rate after myocardial infarction. Ross Fiziol Zh Im I M Sechenova. 2006 Nov;92(11):1305-21. [Article in Russian]

Polunin GS, Nurieva SM, Baiandin DL, Sheremet NL, Andreeva LA. Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease. Vestn Oftalmol. 2000 Jan-Feb;116(1):15-8. [Article in Russian]

Shih-JenTsai. Semax, an analogue of adrenocorticotropin (4–10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome. Medical Hypotheses. Volume 68, Issue 5, 2007, Pages 1144-1146

Kost NV, Sokolov OIu, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA. Bioorg Khim. Semax and selank inhibit the enkephalin-degrading enzymes from human serum. 2001 May-Jun;27(3):180-3. Russian.

Meilandt WJ, Yu GQ, Chin J, et al. Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2008;28(19):5007–5017. doi:10.1523/JNEUROSCI.0590-08.2008

Gusev EI, Skvortsova VI, Chukanova EI, Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(2):35-40. Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency. [Article in Russian]

Gusev EI, Skvortsova VI, Miasoedov NF, Nezavibat'ko VN, Zhuravleva EIu, Vanichkin AV. Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study). Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(6):26-34. [Article in Russian]

 

Selank

he peptide Selank has been labeled as an “anti-anxiety” peptide and has also shown improvement in learning, memory, cognition, depression, weakness and overall energy. 

BENEFITS OF SELANK

While most prescription drugs cause many unwanted side effects, studies have shown this peptide to have no negative side-effects or risk of addiction. Both Tuftsin and Selank have shown the ability to reduce anxiety and increase serotonin levels in animal models.

Additional benefits include:

  • Can improve anxiety 

  • Can improve learning

  • Can enhance memory 

  • Can strengthen immune function: Selank can increase IL-6 in blood cells. IL-6 is an inflammatory protein that is believed to help fight off infections. Selank can also stimulate the release of interferons, which are anti-viral molecules.

  • Can help with brain damage recovery: Increases BDNF (Brain-derived neurotrophic factor), an important brain-growth compound

  • Can help stabilize enkephalins in the blood -- these counteract the stress response

  • Can help with alcohol withdrawal

  • Can help prevent weight gain and reduce cholesterol

 

WHAT IS SELANK?

Selank belongs to a class of molecules called synthetic peptides. Selank was made by combining the sequence of a peptide called tuftsin with another sequence that improves its molecular stability. Tuftsin is a peptide closely related to the immune function. It occurs naturally and makes up one part of the natural antibody IgG.

It is a small peptide compared to most naturally occurring proteins. It was developed at the Institute of Molecular Genetics in cooperation with the V.V. Zakusov Research Institute of Pharmacology (Russian Academy of Medical Sciences), along with the nootropic drug Semax, sometimes called its cousin peptide. 

Selank has been approved in Russia for the treatment of generalized anxiety disorder (GAD) and for its use as a nootropic. In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment of generalized anxiety disorder (GAD).

HOW DO YOU USE SELANK?

Selank is a peptide used as a nasal spray. This is because it will be digested by the stomach if taken orally. Inhaling it is more effective for delivery to the bloodstream and into the brain.

The typical dosage is one spray in each nostril daily.

RESEARCH

In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment of generalized anxiety disorder (GAD).  Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or negative cognitive side effects and no associated addiction or withdrawal problems.

Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48.

Medvedev VE, Tereshchenko ON, Israelian AIu, Chobanu IK, Kost NV, Sokolov OIu, Miasoedov NF. A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22.

Medvedev VE, Tereshchenko ON, Kost NV, Ter-Israelyan AY, Gushanskaya EV, Chobanu IK, Sokolov OY, Myasoedov NF. Optimization of the treatment of anxiety disorders with selank. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(6):33-40. doi: 10.17116/jnevro20151156133-40.

[Article in Russian; Abstract available in Russian from the publisher]

Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, Gabaeva MV, Sokolov OIu, Zozulia AA, Ershov FI. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5. [Article in Russian]

Mjasoedov NF1, Andreeva LA, Grigorjeva ME, Obergan TY, Shubina TA, Lyapina LA.

The influence of Selank on the parameters of the hemostasis system, lipid profile, and blood sugar level in the course of experimental metabolic syndrome. Dokl Biol Sci. 2014 Sep;458:267-70. doi: 10.1134/S0012496614050020. Epub 2014 Nov 5.

Revel M1. Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokine. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5.

Experientia. 1989 Jun 15;45(6):549-57.

Although limited, some of the above evidence suggests that Selank may potentially help curb anxiety and offer many other benefits. More research is always needed to monitor its effectiveness and safety. 

Dihexa

Dihexa (PNB-0408) powder is an Oligopeptide drug, probably even a hexanediol. An Oligopeptide sometime referred to as just a peptide, is a drug that contains dozens of amino acids. Typically, an Oligopeptide may conation anywhere between two to twenty amino acids. Dihexa may also be referred to as PNB – 0408. This was the code name used during the early stages of its development. Dihexa is designed to bind to HGF. Current research has shown that Dihexa may be used to significantly help with cognitive function. Tests done on animal models with Alzheimer’s-like mental impairments showed a lot of promise in using Dihexa as a possible treatment. Besides, the use of Dihexa is not harmful in any way. Most patients who participated in tests did not report any toxicity. Dihexa is largely considered a potent Nootropic drug. It was developed by researchers at Washington State University. At first, the drug was seen as a possible treatment option for trauma-based brain disorders. However, it has found additional applications in improving certain cognitive functions as well including neurodegenerative conditions such as Alzheimer’s.

 

DHHB

DHBB stands dihydrohonokiol-B, (or Dhh-B for short) a powerful anti-anxiety remedy. Take 1-2 in any situation that causes you anxiety or stress and feel relief in less than 20 minutes. It effects are similar to benzodiazapenes and valium but without addiction or unwanted side efftectss

 

Mots-c 

is a Human mitochondrial DNA upregulates the energy production of the cell via the electron transport chain (ETC) complexes. This allows the peptide to promote resistance of metabolic stress by upregulating the mitochondrial genome.. In addition, literature suggests that MOTS-c decreases insulin resistance and increases glucose  uptake in muscle. The peptide is mainly used for weight loss (regulating muscle and fat metabolism) and energy (cell survival in toxic conditions). MOTS-c is consistently used by sports performance athletes to enhance one’s performance. It also displays a promising effect in longevity. The Japanese long-lived people (population with the longest lifespan in the world) have demonstrated a phenotypic expression and biological link between MOTS-c and an extended lifespan.

Bremelanotide

Bremelanotide PT 141 The peptide Bremelanotide PT 141 is now used to treat sexual dysfunction in men and women. But it wasn’t originally intended for this purpose. In fact, this synthetic peptide blend was developed from Melanotan II, a hormone that can darken skin pigmentation and induce tanning.

  1. During initial tests, the discovery that Melanotan II caused sexual arousal and erections as side effects was accidental. These effects occurred in nine out of ten male volunteers in a study conducted at the University of Arizona by Dr. Hunter Wells. Additional research found the hormone acts on the nervous system rather than regulating arousal through the vascular system like medications such as Viagra and Cialis.

  2. How Does Bremelanotide PT 141 Work?

  3. Bremelanotide PT 141 is a non-selective agonist or chemical that binds to and activates a cellular receptor—in this case, the melanocortin receptors associated with pigmentation. Various forms were developed after the peptide was found to be useful in treating sexual disorders. The U.S. Food and Drug Administration (FDA) halted early experiments because test subjects had experienced increases in blood pressure.

  4. In its most current form, Bremelanotide PT 141 is administered via a subcutaneous injection. The most suitable sites for injection are where there are fat deposits. Bremelanotide is, therefore, most often injected into the stomach region, lower abdomen, or thigh. The only legitimate form of the peptide is injectable. Pills, nasal sprays, and creams with the name are not legitimate and should not be administered as such.

  5. Effective dosages may vary as everyone responds differently to the substance. A 2-milligram dose is generally effective for men and women, about 1 hour prior to sexual activity. It’s not recommended to exceed this dosage in 72 hours, but experts suggest starting with a 1-milligram test dose and injecting a similar amount 30 minutes later; testing Bremelanotide in increments to gauge response is considered a safe approach. By consulting a physician or health care provider, you can receive a cycle protocol best suited for your condition.

  6. In tests, some subjects responded to PT 141 in minutes. For others with sexual dysfunction, it took several hours to see the effects. The peptide’s effects can last for up to 72 hours in some people.

  7.  

  8. Cerebrolysin

  9. Cerebrolysin has been proven to have neurotrophic action similar to nerve growth factors causing peripheral and central neuronal stimulation. It improves efficiency within the brain’s aerobic metabolic processes and improves intracellular peptide synthesis. The neuroprotective properties of this nootropic agent help to shield neurons from lactocidosis, to prevent formation of free radicals and to decrease neurotoxic action of certain amino acids. Cerebrolysin is used as a neurotrophic agent for the treatment of ischemic stroke and Alzheimer’s Disease. Exploratory studies in patients with post-acute traumatic brain injury have shown that this treatment might help improve recovery. It now is used for pain syndromes like neuropathy, chronic back pain, sciatica and many others. 

  10.  

  11. Epitalon

  12. Epitalon this peptide truly takes back the aging clock and increases life span peptide by  increasing  telomere size. This pineal peptide increases the sensitivity of hypothalamus to its natural hormonal influences, normalize the function of the anterior pituitary, regulate the levels of gonadotropins and melatonin in the body. Epitalon increases a person’s resistance to emotional stress and also acts as an antioxidant. It is a bio-regulator for the endocrine system, especially for the pineal gland, and has been shown to lengthen telomeres in human cells. The mechanisms of Epitalon are a lot more complex than just activating telomerase. It reduces lipid oxidation and ROS, along with normalizing T cell function. It seems to
    normalize cholesterol and uric acid, along with prolactin levels. It has showed promise in restoring pancreatic hormone function. Additionally, it restored and normalized melatonin levels in older people who have lost some pineal function due to aging.

  13.  

  14. Kissipeptin

  15. this peptide can help stimulate natural testosterone production as well as help maintain optimum levels of testosterone if on topical or injectable therapy. Kisspeptins are a group of neuroendocrine peptides that stimulate the release of Gonadotropin Releasing Hormone (GnRH) and is involved the regulation of developmental sex hormones at the beginning stages of puberty. There have been problems in maturation centered around receptor mutations for kisspeptin. Kisspeptins have shown therapeutic benefits regarding the upregulation of the endogenous production of Luteinizing Hormone (LH) and Follicular Stimulating Hormone (FSH) through the HPA axis. Thus, it can stimulate Leydig cells to produce testosterone without the result of hypogonadism shown with exogenous testosterone usage The expression of Kiss1 has also been altered in other situations of energy imbalance such as obesity and diabetes. It has also been shown to reverse the effects of hypogonadotropic hypogonadism. It also shows other physiologic effects such as helping with egg implantation and maturation in reproduction, as well as the prevention of ectopic pregnancy. Further, in the kidneys it has been shown to increase aldosterone production as well as pregnenolone breakdown and kisspeptin – angiotensin2 production.

 

Aesthetics / Functional Dermatology

Aging is a call for celebration and an opportunity to feel grateful. I believe by deconstructing the common paradigms of the aging process we can fully emerge into our youth at any age. Partnering with our bodies and collaborating with knowledgeable caring doctors, providers, coaches and specialists can allow us to truly harness and reclaim what it means to be and feel beautiful inside and out.  My goal is to support you in aligning your physical and mental health with a tailored natural looking appearance so that you can fully experience a joyful lifestyle that amplifies your own unique exquisiteness.  Wendy Finkelstein embodies the art of integrative health with a heartforward empathetic approach which validates the human experience

Wendy Finkelstein is a board certified Physician Assistant with over a decade of exclusive dermatological and cosmetic experience.  She believes the skin is an important gateway in and out the body and upholds the motto,   if we are not skin conscious than its permeability and functions can be detrimental to our overall health. Coupled with her expert skills in cosmetic and general dermatology, Wendy has a skilled eye when it comes to injectables such as Botox, Dysport, Restylane, Juvederm products and  is  also an expert  in the diagnosis and treatment of skin cancers, acne, psoriasis, eczema and many other common dermatologic disorders

 

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Boca Raton FL South Florida.